Safadi Program of Excellence in Clinical and Translational Neuroscience
Whether in clinical care or medical research, it is critical for physicians and scientists to partner in order to make important advances. This is particularly true in the neurosciences, where the brain presents an immense frontier for scientific advances utilizing collaborative tools and integrative strategies. The Safadi Program of Excellence in Clinical and Translational Neuroscience at the University of Chicago Medicine was launched on April 18, 2017, with the aim of facilitating this multidisciplinary interface, and creating opportunities for collaboration among scientists and clinicians engaged in the diagnosis and treatment of neurological disorders. (Learn more about Mr. Mohammad Safadi.)
Safadi Program Director
John Harper Seeley Professor of Neurological Surgery, Neurology & The Comprehensive Cancer Center
Director, Neurovascular Surgery
James Nelson and Anna Louise Raymond Professor of Neurology
Chair of Neurology
Professor of Neurological Surgery
Director, Neurosurgical Oncology
Interim Chair, Department of Neurological Surgery
Albert D. Lasker Distinguished Service Professor of Neurobiology
Director of the Grossman Institute for Neuroscience
Executive Director, Bucksbaum Institute of Clinical Excellence
Lindy Bergman Distinguished Service Professor of Medicine and Surgery
Director, MacLean Center for Clinical Medical Ethics
Director, Institute for Translational Medicine
Walter L. Palmer Distinguished Service Professor of Medicine and Pediatrics
Dean for Translational Medicine, Biological Sciences Division
Vice Chair for Research, Department of Medicine
Chair, Committee on Molecular Medicine
Professor of Pediatrics
- UChicago Medicine Neurosciences programs
- UChicago Medicine Department of Neurology
- UChicago Medicine Department of Neurological Surgery
- Institute for Translational Medicine
- Bucksbaum Institute for Clinical Excellence
- UChicago Medicine Comprehensive Cancer Center
- Argonne National Laboratory
- Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior
- Institute for Molecular Engineering
- UChicago Department of Neurobiology
Deadline for Submission: December 1, 2023
Project Period: Maximum 12 months, to commence any time after January 1, 2024
Full time faculty in any track at the University of Chicago are invited to apply for Safadi Pilot Grants, to support the generation of preliminary or exploratory data involving novel multidisciplinary neuroscience collaborations, or to help support fellowship training involving novel multidisciplinary tools and concepts.
Proposals should articulate the novel multidisciplinary collaboration, and disease relevance or collaboration with clinical neuroscience group. Applications are due at midnight, December 1, 2023. Decisions about winning proposals will be made before January 1, 2024, and funding for up to 12 months may be requested to commence any time after that date.
Proposals will be evaluated based on:
- Scientific rigor
- The uniqueness of opportunity/infrastructure/milieu
- Contribution to multidisciplinary program development, specifying what disciplines it proposes to bridge
- Potential impact on clinical neuroscience translation or disease applications
- Future directions (i.e. how pilot data will be used for future project application; or how would fellowship support will be leveraged in future career development in multidisciplinary perspective).
The 2023 Safadi Lecture
"How Do You Feel?
The Molecules that Sense Touch"
Professor Ardem Patapoutian
2021 Nobel Laureate in Physiology or Medicine
Presidential Endowed Chair in Neurobiology
Professor, Department of Neuroscience
Investigator, Howard Hughes Medical Institute
Scripps Research Institute
La Jolla, California
We often say that seeing is believing. But touching is also believing. Our sense of touch holds the capacity to connect us with the world and warn us of harm and hurt. But how exactly do you sense a gentle breeze or a cactus pricking your finger? How do you feel the embrace of a loved one? These senses depend on mechanotransduction, the conversion of pressure into chemical signals, which is perhaps the last sensory modality not understood at the molecular level. Dr. Patapoutian will discuss work from his laboratory that identified and characterized PIEZO1 and PIEZO2, pressure-activated cation channels. Genetic studies established that PIEZO2 is the principal mechanical transducer for touch, proprioception, baroreception and bladder and lung stretch, and that PIEZO1 mediates many mechanosensory roles throughout the body. Clinical investigations have confirmed the importance of these channels in human physiology.
Past Safadi Lectures
Beverly L. Davidson2022
"Emerging Gene Therapies for the Central Nervous System"
Christopher A. Walsh2021
"One Brain, Many Genomes: Somatic Mutation and Genomic Diversity in The Human Brain, From Development to Degeneration"
"Neurovascular Pathways to Cognitive Impairment: From Vascular Dementia to Alzheimer's Disease and Beyond"
"Welcome to the Golden Age of Neuroscience"
Mark L. Kahn2018
"The Microbiome and Cerebral Cavernous Malformations"
Safadi Pilot Grant Recipients
Romuald Girard, PhD2023
"Spatial Transcriptome of Cells Constituting Cerebral Microbleeds"
Paschalis Kratsios, MD2023
"Dipeptide Repeat (DPR) Aggregation and Lysosomal Impairment in C9ORF72 ALS/FTD"
Sean Polster, MD2023
"The Influence of the Gut Microbiome on Cerebral Radiation Necrosis"
Sean Foxley, PhD2022
"Using multi-modal, multi-scale imaging for the creation of an accurate 3D cellular atlas of the normal human spinal cord"
Romuald Girard, PhD2022
“Circulating MicroRNAs as Plasma Biomarker of PIK3CA Somatic Mutations in Cerebral Developmental Venous Anomalies Predisposing to CA Development“
William Green, PhD2022
"The Role of Golgi Satellites in Alzheimer’s Disease"
Ying Li, MD, MA2022
“Spatial transcriptomic and proteomic of endothelial cells harboring PIK3CA mutation using GeoMx technology in cerebral cavernous angiomas”
Piyali Saha, PhD2022
"The role of sex hormones and the gut microbiome in Alzheimer’s Disease pathology"
Alfredo J. Garcia, PhD2021
"Neural Mechanisms of Respiratory Instability Due to Chronic Fentanyl Use"
Romuald Girard, PhD2021
"Machine Learning Analyses of in-vivo Brain Permeability and Iron Deposition in the Human Brain with Hemorrhagic Angiopathy"
Stephanie Hage, MD, MSc, MA2021
"Bayesian Adaptive Design in Phase IIA Biomarker Trial"
Martin Herman, MD, PhD2021
"Implantation of Wireless Floating Multielectrode Arrays into Lumbar Spinal Cord for the Control of Locomotion in Yucatan Pigs"
Xiaoxi Zhuang, PhD2021
"The Contribution of Mild Pyridoxine 5’-Phosphate Oxidase (PNPO) Deficiency to Epilepsy in Children"
Siri Atma W. Greeley, MD, PhD2020
"Examining the neurodevelopmental role of KCNJ11 in patient-derived cerebral organoids"
Bakhtiar Yamini, MD2019
"NF-κB and the Microbiome in Neurodegeneration"
Hemraj B. Dodiya, PhD2019
"Role of Intestinal Hyperpermeability “leaky gut” in Alzheimer’s Disease Pathogenesis"
Dongdong Zhang, MD2019
"The Antigen Recognition Study in Cerebral Cavernous Malformation Disease"
Sean Polster, MD2018
"Differential Transcriptome of Human Cerebral Hemorrhagic Microangiopathy"
Le Shen, PhD2018
"Effect of Cerebral Cavernous Malformation Genes on Intestinal Epithelium"